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COVID-19 hasn’t gone away1,2

COVID-19 hasn’t gone away1,2

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Long-term health risks remain3,4Patients may face complications after acute infection
New-onset medical conditions
Exacerbation of existing conditions
Persistent symptoms
COVID-19 doesn’t behave like other respiratory viruses5 Unlike flu and RSV, COVID-19 regularly peaks in both winter and summer2,6 Unchecked viral replication can trigger systemic inflammation across the heart, lungs, brain, kidneys, and vascular system.7,8In a study comparing COVID-19 and influenza cases, COVID-19 patients had9: higher risk of post-acute sequelae requiring hospitalization within 31 to 90 days compared to flu patients higher risk of post-acute sequelae requiring hospitalization within 31 to 90 days for those initially hospitalized with COVID-19, compared with hospitalized flu patientsRepeat infections multiply risk Underlying chronic conditions lower the body’s baseline resilience, increasing the risk of severe COVID-19 in adults of any age3,10Risk Factors

Learn why staying up to date on risk factors is crucial to care

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RSV=respiratory syncytial virus.

References:National wastewater data for respiratory viruses. Centers for Disease Control and Prevention. Updated July 17, 2026. Accessed August 28, 2026. https://www.cdc.gov/wastewater/respiratory-viruses/national.html2025-2026 Respiratory Disease Season Outlook – December Update. Centers for Disease Control and Prevention. August 25, 2025. Accessed August 7, 2026. https://www.cdc.gov/cfa-qualitative-assessments/php/data-research/season-outlook25-26-dec-update.htmlBowe B, Xie Y, Al-Aly Z. Acute and postacute sequelae associated with SARS-CoV-2 reinfection. Nat Med. 2022;28(11):2398-2405.Long COVID signs and symptoms. Centers for Disease Control and Prevention. Updated March 9, 2026. Accessed August 7, 2026. https://www.cdc.gov/long-covid/signs-symptoms/index.htmlSimilarities and differences between flu and COVID-19. Centers for Disease Control and Prevention. Updated September 17, 2024. Accessed August 7, 2026. https://www.cdc.gov/flu/about/flu-vs-covid19.htmlRespiratory Virus Hospitalization Surveillance Network (RESP-NET). Centers for Disease Control and Prevention. Updated January 30, 2026. Accessed August 18, 2026. https://www.cdc.gov/resp-net/dashboard/index.htmlRamos SG, Rattis BADC, Ottaviani G, Celes MRN, Dias EP. ACE2 down-regulation may act as a transient molecular disease causing RAAS dysregulation and tissue damage in the microcirculatory environment among COVID-19 patients. Am J Pathol. 2021;191(7):1154-1164.Gupta A, Madhavan MV, Sehgal K, et al. Extrapulmonary manifestations of COVID-19. Nat Med. 2020;26(7):1017-1032.Lewnard JA, Malden DE, Hong V, et al. Comparative risk of post-acute sequelae following SARS-CoV-2 or influenza virus infection: a retrospective cohort study among United States adults. PLoS Med. 2025;22(10):e1004777.Ernst FR, McGrath L, Reimbaeva M, et al. Impact of risk stacking on COVID-19-related healthcare utilization: a real-world retrospective cohort study. Infect Dis Ther. 2026;15(1):327-343.

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